How to Choose the Best ADHD Medication for Adults With Anxiety and Depression If someone has ADHD and depression or anxiety treating one condition usually improves the other. Mental health professionals prescribe antidepressants, stimulants for depression, or antidepressants, along with ADHD medication. Wellbutrin (bupropion) and Effexor (venlafaxine) are the most frequently used antidepressants prescribed "off-label" for ADHD. These medications increase levels of neurotransmitters like no...